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Dicer Is Required for Embryonic Angiogenesis during Mouse Development
2004
Journal of Biological Chemistry
Dicer is a multi-domain protein responsible for the generation of short interfering RNAs (siRNAs) from long double-stranded RNAs during RNA interference. It is also involved in the maturation of microRNAs, some of which are transcriptional regulators of developmental timing in nematodes. To assess the role of Dicer in mammals, we generated Dicer ex1/2 mice with a deletion of the amino acid sequences corresponding to the first and second exons of the dicer gene via homologous recombination. We
doi:10.1074/jbc.m413394200
pmid:15613470
fatcat:txhc2jdjajao5fvrrba7ksnlbe