717 INTERNATIONAL JOURNAL OF PHARMACEUTICAL, CHEMICAL AND BIOLOGICAL SCIENCES SYNTHESIS , CHARACTERIZATION AND COMPUTATIONAL STUDY OF SOME NEW 5-(FURAN-2-YL)-3-PHENYL-4,5-DIHYDROISOXAZOLE DERIVATIVES FROM CHALCONE COMPOUNDS

Abbas Abbas, Nesreen Majeed, Afaq Turki
IJPCBS   unpublished
INTRODUCTION Compounds with isoxazoline structures are known to possess a wide spectrum of activities like antifungal, anticancer, antiviral and insecticidal and are also important precursors for different natural products 1-4. Prodrug-based monoamine oxidase (MAO) inhibitors having hydrazide, hydrazine and amine moiety such as isocarboxazide 5 , phenelzine 6 and meclobemide 7,8 show prominent antidepressant activity in laboratory animals and human. Additionally, tranylcypromine-like MAO
more » ... ine-like MAO inhibitors are mechanism based inactivators and they are metabolized by MAO with one electron of the nitrogen pair and to generate an imine, the other residing on a methylene carbon (R-C=NH2+). The structures of the synthesized 2-isoxazoline derivatives are very similar to those of isocarboxazid (Fig. 1).
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