Aims High-grade conduction disturbances requiring permanent pacemaker (PPM) implantation occur in up to 40% of patients following transcatheter aortic valve implantation (TAVI). The aim of this study was to identify pre-operative risk factors for PPM implantation after TAVI with the Medtronic CoreValve prosthesis (CVP). Methods and results We retrospectively analysed 109 patients following transfemoral CVP implantation performed between 2008 and 2009 at the Leipzig Heart Center. Patients who

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... indwelling PPM at the time of TAVI (n ¼ 21) were excluded, leaving 88 patients for analysis. Mean age was 80.3 + 6.6 years and logistic EuroScore predicted risk of mortality was 23.3 + 12.1%. A total of 32 patients (36%) underwent PPM implantation post-TAVI during the same hospital admission. A total of 27/88 (31%) had evidence of pre-operative abnormal conduction, including first degree AV block and left bundle brunch block. Statistically significant risk factors for the need for post-operative PPM were patient age .75 years [P ¼ 0.02, odds ratio (OR) 4.6], pre-operative heart rate ,65 beats per minute (b.p.m.; P ¼ 0.04, OR 2.9), CVP oversizing .4 mm (P ¼ 0.03, OR 2.8), CVP prosthesis .26 mm (OR 2.2), atrial fibrillation (P ¼ 0.001, OR 5.2), and ventricular rate ,65 b.p.m. at the first post-operative day (P ¼ 0.137, OR 6.0). Conclusion PPM implantation occurs frequently after transfemoral TAVI with the CVP. Older age, chronic atrial fibrillation, preoperative bradycardia, and larger or significantly oversized prostheses were independent risk factors for PPM implantation following TAVI with the CVP. --- Keywords Aortic valve stenosis † Trans-catheter aortic valve replacement † Atrio-ventricular block † Pacemaker