Observation thus far goes to show that a certain deep-seated affection of the eye, characterized by a deposit of pigment on the retina and terminating inevitably in blindness, occurs in from 40 to 50 per cent, of the cases in the offspring of the intermarriage of blood relations. I have thought that the exhibition of such a case to the Society, and the demonstration to them of the retinal changes by the aid of the fixed ophthalmoscope, might not be devoid of interest to those even not specially

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... interested in the subject of ophthalmic disease. M. K., aged 24, entered the Eye Infirmary a few days since, under the care of Dr. P. P. Sprague. She complained chiefly of imperfect vision, which had been gradually increasing since tho age of 12. When first troubled in this way, she procured a pair of strong convex glasses, and has read and studied with them up to within six months of tho present time, since when, alarmed at the continued failure of vision, she has refrained from all use of the eyes on near objects. Has long been aware that by twilight and in the evening lier vision was not as good as other people's. Her general health has always been reasonably good, though she has never been very robust. Catamonia quite regular as to time, though rather deficient in quantity. The eyes externally are of normal appearance, except that there is a divergent strabismus of about 2'" on tho left side. Each field of vision is much narrowed upwards and inwards. As compared with the normal standard, or unity, the vision of the right eye would be expressed by the fraction ¿, that of the left by TV-ïuc ophthalmoscope reveals almost precisely the condition of things pictured in