In order to clarify the correlation between serum levels of thyroid hormone and prolactin response to the thyrotropin-releasing hormone (TRH), untreated hyperthyroidism with diffuse goiter, euthyroid hyperthyroidism with PTU and primary hypothyroidism were employed. Group A (n=7) was untreated hyperthyroidism with mean values of 15.6 ± 0.5Pg/ 100m1 (T4) and 467.7 ± 80.4ng/100m1 (T3); Group B (n=5) was PTU treated hyperthyroidism in euthyroid state within 6 months, with 9.3 ± 0.6pg/100m1 (T4)

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... 174 .0 ± 16.1ng/ 100m1 (T3); Group C (n=10) consisted of subjects similar to those in group B with 1-2 yrs of euthyroidism, with 8.7 ± 1.4µg/ 100m1 (T4) and 146.2 ± 19.1ng/100m1 (T3); Group D consisted of subjects similar to those in groups B and C with a euthyroid state over 2 yrs, with 9.0 ± 0.5pg/100m1 (T4) and 122.8 ± 7.1ng/100m1 (T3) (n=13); Group E (n=8) was primary hypothyroidism before any treatment with 3.3 ± 0.4pg/100m1 (T4) and 51.0 ± 6.6 ng/100m1 (T3). Serum values of the thyroid hormones (T4 and T3) fell from group A to group E, and in each group, thyroid hormone levels in serum were considered to be in a relatively constant range over a long term. Serum levels of TSH, PRL and T3 were determined following a 500pg TRH injection in all groups. Although dissociation between PRL and TSH responses to the TRH provocation was seen in some groups, it seemed that both responses were inversely augmented according to the decrease of serum thyroid hormone levels. Therefore, statistical analyses 第54巻 第11号