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This paper deals with the design of mixed thermally coupled-heat integrated distillation sequences. The approach considers from conventional columns (each distillation column with a condenser and a reboiler) to fully thermally coupled systems (only one reboiler and one condenser in the entire system). A discussion about superstructure generation and the convenience of using a representation based on separation tasks instead of equipment is presented, as well as a set of logical rules in termsdoi:10.1021/ie060030w fatcat:lvtagmlatredlj65vznl3ougdi