Predictive value of preoperative neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in surgical site infection following radical resection for rectal cancer

Yi-chen LIU, Xi-ru LI, Xiao-hui DU, Song-yan LI, Shi-dong HU, Yu YANG, Yu-xuan LI, Bo-yan LIU, Xiao-lei XU, Xiao-wei XING, Chang-zheng HE, Hong-liang ZHANG (+1 others)
2019 Medical Journal of Chinese People's Liberation Army  
Objective To investigate the predictive value of preoperative neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in surgical site infection (SSI) following radical resection for rectal cancer. Methods Retrospective analysis of clinical data was performed about 298 patients undergoing radical resection of rectal cancer in the Chinese PLA General Hospital from January 2015 to February 2018. According to whether SSI occurred 30 days after surgery, patients were divided into SSI group
more » ... ded into SSI group (n=20) and control group (n=278). Gender, age, preoperative neoadjuvant chemoradiation, surgical procedure, T stage, and preoperative neutrophil count, lymphocyte count, platelet count, neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), albumin, and hemoglobin level were compared between the two groups. Subgroup analysis was performed in the SSI group according to laparotomy and minimally invasive surgery. Gender, age, preoperative neoadjuvant chemoradiation (CRT), T stage, and preoperative neutrophil count, lymphocyte count, platelet count, NLR, PLR, albumin, and hemoglobin level were compared between two the subgroups. The predictive value of preoperative NLR and preoperative PLR in surgical site infection following radical resection for rectal cancer were analyzed by receiver operating characteristic (ROC) curve. Results The ratio of male to female in the SSI group is higher than control group (19/1 vs. 178/100, P=0.005). There was no significant difference in other demographic and clinical data such as age, non-restorative operation ratio, minimally invasive surgery ratio, neoadjuvant CRT ratio, T stage, preoperative albumin and preoperative hemoglobin between the two groups (P>0.05). There was no significant difference in preoperative neutrophils count [(3.96±1.03)×109/L vs. (3.62±1.28)×109/L, P=0.245], lymphocytes count [(1.47±0.45)×109/L vs. (1.71±0.64)×109/L, P=0.103] and platelets count [(249.10±57.42)×109/L vs. (230.21±68.53)×109/L, P=0.231] between the two groups. Preoperative NLR in the SSI g [...]
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