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Phorbol ester effects on splenic lymphocyte composition and cytotoxic T cell activities of SSIN mice: a strain deficient in CD8+ T cells
SSIN mice are considerably more sensitive to the effects of 12-0-tetradecanoylphorbol-13-acetate (TPA) in two-stage skin carcinogenesis protocols than are most other strains and stocks of mice. Experiments were performed to determine whether there was an immunological basis for this sensitivity. SSIN mice were haplotyped and found to be H-2 q . T cells represented -31% of the splenic cellularity of non-treated SSIN mice, but -44% in BALB/c, C57BL/6, B 6 C3Fi and SENCAR mice. Splenic CD4+/CD8+ Tdoi:10.1093/carcin/17.12.2617 pmid:9006097 fatcat:6iqsn23efzb4xgx4rto5mnzmoq