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Statins are the cornerstone of pharmacotherapy for atherosclerotic cardiovascular disease. While these drugs are generally safe, treatment adherence is not optimal in a considerable proportion of patients because of the adverse effects on skeletal muscles in the forms of myopathy, myalgia, muscular pain, nocturnal muscle cramping, weakness, and rare rhabdomyolysis. For the purpose of this narrative review, we searched for the literature suggesting the involvement of the ubiquitin-proteasomedoi:10.1002/jcsm.12579 pmid:32743965 fatcat:stdutksgxzgjto37qr7dqlkuzy