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p75 NTR , a nerve growth factor co-receptor that has been implicated in apoptosis of neurons, is structurally related to Fas and the receptors for tumor necrosis factor-␣ that display ligand independent assembly into trimers. Using embryonic day 17 fetal rat cortical neurons and p75 NTR -expressing NIH-3T3 cells, we now show that p75 NTR exists as a trimer as well as a monomer. Furthermore, we have reported and others have confirmed that amyloid ␤ binds p75 NTR , and that this binding leads todoi:10.1074/jbc.m110929200 pmid:11756426 fatcat:c2zqgg5evbao7hzkwkvpx2dfvy