Beneficial Effects of a Soy-Based Dietary Supplement on Lipid Levels and Cardiovascular Risk Markers in Type 2 Diabetic Subjects

K. Hermansen, M. Sondergaard, L. Hoie, M. Carstensen, B. Brock
2001 Diabetes Care  
L.H. is on the Board of Directors of, is paid consulting fees by, and holds stock in Nutri Pharma ASA. Abbreviations: apo, apolipoprotein; BP, blood pressure; CAD, coronary artery disease; ELISA, enzymelinked immunosorbent assay; Lp(a), lipoprotein(a); PAI-1, plasminogen activator inhibitor 1. A table elsewhere in this issue shows conventional and Système International (SI) units and conversion factors for many substances. OBJECTIVE -Consumption of soy protein has recently been shown to improve
more » ... the blood lipid levels in nondiabetic subjects. The purpose of this study was to evaluate if a dietary supplement of soy protein, isoflavones, and cotyledon fiber (Abalon) affects cardiovascular risk markers, blood glucose, and insulin levels in type 2 diabetic subjects. RESEARCH DESIGN AND METHODS -Twenty type 2 diabetic subjects participated in a crossover trial. They were randomized to double-blind supplementation for 6 weeks with Abalon (soy protein [50 g/day] with high levels of isoflavones [minimum 165 mg/day] and cotyledon fiber [20 g/day]) or placebo (casein [50 g/day] and cellulose [20 g/day]), separated by a 3-week wash-out period. RESULTS -The results are expressed as means ± SD. The percentage mean treatment difference between Abalon and placebo demonstrated significantly lower mean values after Abalon for LDL cholesterol (10 ± 15%, P Ͻ 0.05), LDL/HDL ratio (12 ± 18%, P Ͻ 0.05), apolipoprotein (apo) B100 (30 ± 38%, P Ͻ 0.01), triglycerides (22 ± 10%, P Ͻ 0.05), and homocysteine (14 ± 21%, P Ͻ 0.01), whereas the total cholesterol value tended to be less significant but still lower (8 ± 15%, P Ͻ 0.08). No change occurred in HDL cholesterol, apo B100/apo A1 ratio, plasminogen activator inhibitor 1, factor VIIc, von Willebrand factor, fibrinogen, lipoprotein(a), glucose, HbA 1c , or 24-h blood pressure. CONCLUSIONS -These results indicate beneficial effects of dietary supplementation with Abalon on cardiovascular risk markers in type 2 diabetic subjects. This improvement is seen even in individuals with near-normal lipid values.
doi:10.2337/diacare.24.2.228 pmid:11213870 fatcat:2syw333jffdfveutfhrbox7koq