Accidental splash exposure is one of the common occupational health related problem among health care workers. The problem is worse in developing countries in which the safety practice and protective devices do not properly used. However, little is known on the prevalence and associated factors for splash exposure. Therefore, the main objective of this study was to determine the prevalence of self reported splash exposure and factors that influence those exposures. Methods: Institutional based

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... ross sectional study was done from January 1 to 30, 2014 in Hawassa Referral and Adare District Hospitals. Physicians, nurses, laboratory technicians/ technologists, midwifes, health officers, cleaners, porters and laundry workers were involved in the study. Self administered questionnaires were used for those who can read and understand easily and interview was carried out for those who can't read and understand. Data was analyzed using SPSS version 16 and logistic regression was carried out to assess the association of selected independent variables with accidental splash exposure. Results: The prevalence of one episode of splash exposure was 28%. There was twofold increased risk of blood and body fluids exposure among health care workers who have multiple responsibilities (AOR = 2.39, 95% CI: 1. 27-4.49). Similarly, the risk of exposure was doubled among health care workers who washed linen in the institution (AOR = 2. 30, 95% CI: 1.37-3.84) and among those who work in delivery and operation room (AOR = 2.20, 95% CI: 1.10-4.40). Conclusions: Splash exposure is common among health care workers in the study hospitals which warrantee occupational health and safety training.