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Intermedin protects against renal ischemia-reperfusion injury by inhibition of oxidative stress
AJP - Renal Physiology
Intermedin protects against renal ischemia-reperfusion injury by inhibition of oxidative stress. oxygen species (ROS) play a critical role in renal ischemia-reperfusion injury (IRI). Intermedin (IMD) reportedly protected against myocardial IRI via its antioxidant effects; however, its protective role in renal IRI has not been investigated. We overexpressed IMD in rat kidneys and examined how the kidneys respond to renal IRI. Eukaryotic expression plasmid encoding the rat IMD gene or controldoi:10.1152/ajprenal.00054.2012 pmid:23077098 fatcat:ddzfjdvhazaelmqt5eqplksk6m