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Bacteroides fragilis is the leading cause of anaerobic bacteremia and sepsis 1 . Enterotoxigenic strains producing B. fragilis toxin (BFT, fragilysin) contribute to colitis 2 and intestinal malignancy 3 , yet are also isolated in bloodstream infection 4 , 5 . It is not known whether these strains harbor unique genetic determinants that confer virulence in extra-intestinal disease. We demonstrate that BFT contributes to sepsis and identify a B. fragilis protease, fragipain (Fpn), which isdoi:10.1038/nm.4077 pmid:27089515 pmcid:PMC4860040 fatcat:z32zejfymvgnhemuboqc56ukoa