Background: Central serous chorioretinopathy (CSC) is a disorder characterised by serous detachment of the retina and is associated with retinal pigment epithelium (RPE) alteration. Flat irregular pigment epithelium detachment (FIPED) is one of the pigment epithelial detachment (PED) patterns of CSC and it is associated with chronic CSC.This study investigated choroidal neovascularisation (CNV) in FIPED with en-face optical coherence topography angiography (OCTA) and cross-sectional OCTA, to

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... luate the incidence of CNV and compare the efficacy of each method. Methods: We retrospectively studied OCT and OCTA images of 328 eyes with CSC. OCTA B-scans and macular cube were primarily reviewed for the detection of FIPED and CNV. En-face OCTA and cross-sectional OCTA with Angio-B view, which is an image that combines an OCT B-scan with a flow signal were analysed to evaluate the presence of CNV in FIPED.Results: CNV was observed in 23 eyes on en-face OCTA and 21 eyes on cross-sectional OCTA, among 93 eyes of 88 patients with FIPED. There were eight discrepant cases, in which result of en-face OCTA was not equal to that of cross-sectional OCTA. Conclusions: The CNV and FIPED lesions were well detected on cross-sectional and en-face OCTA. Integration of these two methods can potentially improve the utility and diagnostic accuracy of OCTA.