The dissertation describes two different approaches to the synthesis of hybrid catalytic systems. On the one hand it was possible to conduct a Huisgen cycloaddition within the active site of the carbonic anhydrase II. The azide was bound covalently to the enzyme while the alkyne was anchored via a sulfonamide to the active site. The reaction could be monitored via crystal structural analysis and mass spectroscopic analysis. On the other hand the dissertation deals with contributions to the

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... esis of a hydrogenation catalytic system consisting of a phosphine-rhodium-complex covalently bound to the carbonic anhydrase II. In the course of this work a water soluble phosphine-ligand could be synthesized with different reactive groups for covalent attachment to a cysteine.