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Probing the substrate specificity of the intracellular brain platelet-activating factor acetylhydrolase
Protein Engineering Design & Selection
Platelet-activating factor acetylhydrolases (PAF-AHs) are unique PLA2s which hydrolyze the sn-2 ester linkage in PAF-like phospholipids with a marked preference for very short acyl chains, typically acetyl. The recent solution of the crystal structure of the α 1 catalytic subunit of isoform Ib of bovine brain intracellular PAF-AH at 1.7 Å resolution paved the way for a detailed examination of the molecular basis of substrate specificity in this enzyme. The crystal structure suggests that thedoi:10.1093/protein/12.8.693 pmid:10469831 fatcat:lpbe56tbijenhodch5aj4ar23e