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Migrating cells mediate long-range WNT signaling
Journal of Cell Science
In amniotes, it is widely accepted that WNTs secreted by the dorsal neural tube form a concentration gradient that regulates early somite patterning and myotome organization. Here we demonstrate in the chicken embryo that WNT protein is not secreted to act at a distance, but rather loaded onto migrating neural crest cells that deliver it to somites. Inhibiting neural crest migration or ablating their population has a profound impact on the WNT response in somites. Furthermore, we show that adoi:10.1242/jcs.155705 fatcat:sxhx24x3hfderd4fnbtlbhzbtu