The aim of the study was to evaluate the potential effect of Malva sylvestris(M. sylvestris) extract on nephrotoxicity caused by CCl 4 in rats. Forty rats were divided into four equal groups. Group 1: negative control group (normal).Group2: positive group, treated with CCl 4 (1ml/kg body weight (b.w)), twice a week for 8 weeks. Groups 3 and 4 were treated with the same dose of CCl 4 coadministered with M. sylvestris at dose 150 or 300 mg/kg b.w, respectively. Results appeared that rats treated

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... ith CCl 4 showed a significant increment in WBCs, kidney function (urea and creatinine), total lipid, cholesterol, triglycerides, glucose, malondialdehyde (MDA), and nitric oxide (NO) levels, but a significant decline in the mean values of weight gain, RBCs, PCV, Hb, uric acid, and catalase (CAT) as comparing with the control group. The treatment with M. sylvestris(150 and 300 mg/kg b.w) improved the hematological and biochemical parameters. These protective effects were dose dependent. The histological results confirmed these parameters that enhanced by CCl 4 Thus, the extract of M. sylvestris represents an encouraging chance for the curative renal injury.