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Hemoglobin drives inflammation and initiates antigen spread and nephritis in lupus
Hemoglobin (Hb) has well-documented inflammatory effects and is normally efficiently scavenged; clearance mechanisms can be overwhelmed during conditions of erythrocyte lysis, a condition that may occur in systemic lupus erythematosus. Whether Hb is preferentially inflammatory in lupus and additionally induces autoreactivity against prominent autoantigens was assessed. Peripheral blood mononuclear cells derived from SLE patients secreted higher levels of lupus-associated inflammatory cytokinesdoi:10.1101/2020.11.27.399501 fatcat:zaadlj7oibhajowdnf3ihj45se