Computer Aided Design (CAD) tools are extensively used to design industrial components, however contrary to e.g. Computational Fluid Dynamics (CFD) solvers, shape sensitivities for gradient-based optimisation of CAD-parametrised geometries have only been available with inaccurate and non-robust finite differences. Here Algorithmic Differentiation (AD) is applied to the open-source CAD kernel Open CASCADE Technology using the AD software tool ADOL-C (Automatic Differentiation by OverLoading in

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... +). The differentiated CAD kernel is coupled with a discrete adjoint CFD solver, thus providing the first example of a complete differentiated design chain built from generic, multi-purpose tools. The design chain is demonstrated on the gradient-based optimisation of a squared U-bend turbo-machinery cooling duct to minimise the total pressure loss.