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Objective. Urban regeneration can be considered a population health intervention (PHI). It is expected to impact on population health but the evidence is limited or weak, in part due to the difficulties of evaluating PHIs. We explore these challenges using GoWell as a case study. Method. A 10-year evaluation of housing improvement and urban regeneration in 15 deprived areas in Glasgow, Scotland (2005-2015. Results. Challenges faced include: definition and changing nature of the intervention;doi:10.1016/j.ypmed.2013.08.007 pmid:23954184 fatcat:io26oc75pbhs7bbayhyvqurwsu