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Postinfarction Treatment With an Adenoviral Vector Expressing Hepatocyte Growth Factor Relieves Chronic Left Ventricular Remodeling and Dysfunction in Mice
2003
Circulation
Background-Hepatocyte growth factor (HGF) is implicated in tissue regeneration, angiogenesis, and antiapoptosis. However, its chronic effects are undetermined on postinfarction left ventricular (LV) remodeling and heart failure. Methods and Results-In mice, on day 3 after myocardial infarction (MI), adenovirus encoding human HGF (Ad.CAG-HGF) was injected into the hindlimb muscles (nϭ13). As a control (nϭ15), LacZ gene was used. A persistent increase in plasma human HGF was confirmed in the
doi:10.1161/01.cir.0000065579.19126.b8
pmid:12695295
fatcat:xgxib5gbafaxzjz7xdfaf45q24