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The 3′UTR signature defines a highly metastatic subgroup of triple-negative breast cancer
2016
OncoTarget
Triple-negative breast cancer (TNBC) is a highly heterogeneous disease with an aggressive clinical course. Prognostic models are needed to chart potential patient outcomes. To address this, we used alternative 3′UTR patterns to improve postoperative risk stratification. We collected 327 publicly available microarrays and generated the 3′UTR landscape based on expression ratios of alternative 3′UTR. After initial feature filtering, we built a 17-3′UTR-based classifier using an elastic net model.
doi:10.18632/oncotarget.10975
pmid:27494850
pmcid:PMC5312352
fatcat:enham27avvgabbicvqesabha3m