Toxicological and Chemical-Ecological Studies on Insect Control

Izuru YAMAMOTO
1984 Journal of pesticide science  
The purposeful rational design of insect control chemicals was based on studies of the mechanism and selectivity of insecticide action and of the chemical basis of insect behavior. I. Toxicological studies on insecticides. Studies on structure-activity relationships of nicotinoids demonstrated that the active nicotinoids should resemble acetylcholine with respect to their conformation and electronic makeup. The mode of insecticidal action elucidated provided the basis for developing new
more » ... -containing insecticides. Investigations on the fate of rotenone in various biological and photodecomposition systems and synthesis of its transformation products, as well as all possible stereoisomers of rotenone, enabled the analysis of the essential feature necessary for exerting its toxic action. A stereostructure defined by a 6af, 12af-configuration and hydrophobicity were essential. Also elucidation of the metabolic pathways of natural and certain synthetic pyrethroids formed the basis for understanding selectivity, resistance mechanisms, synergism and, with information on photoconversion,
doi:10.1584/jpestics.9.551 fatcat:fjsnwjyvf5euxmilukyptqp2um