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The purposeful rational design of insect control chemicals was based on studies of the mechanism and selectivity of insecticide action and of the chemical basis of insect behavior. I. Toxicological studies on insecticides. Studies on structure-activity relationships of nicotinoids demonstrated that the active nicotinoids should resemble acetylcholine with respect to their conformation and electronic makeup. The mode of insecticidal action elucidated provided the basis for developing newdoi:10.1584/jpestics.9.551 fatcat:fjsnwjyvf5euxmilukyptqp2um