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AbstractLungfishes belong to lobe-fined fish (Sarcopterygii) that in the Devonian 'conquered' land and gave rise to all land vertebrates, including humans1–3. We determined the largest chromosome-quality animal genome, the Australian lungfish, Neoceratodus forsteri. Its vast size (~14x of human) is attributable mostly to huge intergenic regions and introns with high repeat content (≈90%) whose components resemble tetrapods more (mostly LINE elements) than ray-finned fish. The lungfish genomedoi:10.1038/s41586-021-03198-8 pmid:33461212 fatcat:wqj42ctuizaplh6be4sxyav4r4