Antimelanomal Activities of some Newly Synthesized Pyrrolotriazolopyrimidines and Pyrrolotetrazolopyrimidines and their Derivatives

Alhussein A. Ibrahim, Mohamed F. El-Shehry, Hanaa M. Hosni, Abd El-Galil E. Amr, Mohamed M. Abdalla
2015 International Journal of Pharmacology  
A B S T R A C T A series of pyrrolo [2,3-d] pyrimidine, pyrrolotriazolopyrimidine and pyrrolotetrazolopyrimidine derivatives 2-13 were synthesized using 2-amino-1-(3-(trifluoromethyl)phenyl)-4,5-bis (4-methoxy-phenyl)-1H-pyrrole-3-carbonitrile 1 as starting material. The biological rational upon which the newly synthesized compounds was built was their structural similarity with some pyrrole derivatives that having antimelanomal, anti-tetrahymena and some kinases inhibitor activities. Some of
more » ... e newly synthesized compounds showed antimelanomal, anti-tetrahymena and some kinases inhibitor activities of the 124 kinases panel.
doi:10.3923/ijp.2015.806.813 fatcat:ptj6cctdybhftbdlnus2qsos6e