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Tissue gene expression is generally regulated by multiple transcription factors (TFs). A major first step toward understanding how tissues achieve their specificity is to identify, at the genome scale, interacting TFs regulating gene expression in different tissues. Despite previous discoveries, the mechanisms that control tissue gene expression are not fully understood. Results: We have integrated a function conservation approach, which is based on evolutionary conservation of biologicaldoi:10.1186/1471-2164-11-49 pmid:20955586 pmcid:PMC3091724 fatcat:apsxofjzdngrjjqsvi5uctejra