Human parvovirus B19 is a single-stranded DNA and non-enveloped virus which belongs to the Parvoviridae family. The virus spreads through respiratory secretions and perinatal blood. B19 may cause serious complications in patients with cellular immunodeficiency that have no detectable antibodies to B19, such as aplastic crises in solid organs. Objectives: The present study aimed to investigate the prevalence of parvovirus B19 and to evaluate the presence of B19 DNA among blood donors in Golestan

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... Province. Methods: Sera of 400 blood donors in Golestan Province who were negative for HIV, HbsAg, and HCV were tested for both IgG and IgM anti-B19 virus antibodies using the ELISA method, following which all sera were tested for the presence of B19 DNA by semi-nested PCR. Results: 242 (out of 400) subjects (60.5%; 95% CI) were positive for anti-B19 IgG, and 158 were negative for IgG antibody (39.5%; 95% CI). Moreover, all asymptomatic blood donors were negative for anti-B19 IgM. No viral genome was found in serum samples of donors. Conclusions: Since no viral genome was found in the donors' serum samples and the relatively high prevalence of anti HPV- B19 IgG in blood donors, it can be concluded that the possibility of B19 transmission through blood transfusion is low. However, special caution should be taken when transfusing blood to the high-risk groups such as pregnant women, immune-deficient patients, and those with hematological problems, particularly regarding IgG anti- HPV- B19 antibodies (HPV- B19-safe).