Fernández-Cuadros ME, Pérez-Moro O, Albaladejo-Florin MJ, Álava-Rabasa S. El ozono intrarticular modula la inflamación, mejora el dolor, la rigidez, la función y tiene un efecto anabólico sobre la artrosis de rodilla: estudio cuasiexperimental prospectivo tipo antes-después, 115 pacientes. Rev Soc Esp Dolor 2020;27(2): [78][79][80][81][82][83][84][85][86][87] [88] El ozono intrarticular modula la inflamación, mejora el dolor, la rigidez, la función y tiene un efecto anabólico sobre la artrosis

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... e rodilla: estudio cuasiexperimental prospectivo tipo antes-después, 115 pacientes Intra-articular ozone modulates inflammation, ameliorates pain and stiffness, improves function and has anabolic effect on knee osteoarthritis: a prospective quasiexperimental before-and-after study, 115 patients ABSTRACT Purpose: The objective of the present study is to verify for the first time in the literature the symptomatic and modifying disease effect of ozone (O 2 -O 3 ) through clinical (pain, function and stiffness), biochemical (C-reactive protein [CRP], erythrocyte sedimentation rate [ESR], uric acid) and radiological improvement (minimum medial and lateral joint space) in a series of patients with osteoarthritis of the knee. Methods: A prospective quasi-experimental beforeand-after study was performed in 115 patients with knee osteoarthritis Kellgren-Lawrence grade 2 or more. The ozone protocol consisted of 4 sessions (one session / week) of an intra-articular injection of 20 ml of a medical mixture of Oxygen-Ozone (95-5ºC) at a concentration of 20 µg / ml. Outcome variables included clinical (pain, stiffness, and function), biochemical (CRP, ESR, uric acid), and radiological variables (minimal femorotibial joint space). Results: Mean age of the patients was 64.81 ± 11.22 years. Female patients accounted for 75.6 % (n = 87), with a female / male ratio of 3 : 1. Biochemical-variables: CRP decreased from 0.42 ± 0.54 mg/dL to 0.31 ± 0.33 mg/dL (p = 0.0142). Palabras clave: Ozono, biomarcadores, dolor, WOMAC, artrosis, rodilla. 80 M. E. FERNÁNDEZ-CUADROS ET AL. Rev. Soc. Esp. del Dolor, Vol. 27, N.º 2, Marzo-Abril 2020 BIBLIOGRAFÍA