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Wnt-3A/beta -Catenin Signaling Induces Transcription from the LEF-1 Promoter
Journal of Biological Chemistry
Members of the Wnt family of secreted molecules have been established as key factors in determining cell fate and morphogenic signaling. It has long been recognized that Wnt induces morphogenic signaling through the Tcf/LEF-1 cascade by regulating free intracellular levels of ␤-catenin, a co-factor for Tcf/LEF-1 transcription factors. In the present study, we have demonstrated that Wnt-3A can also directly induce transcription from the LEF-1 promoter. This induction was dependent on glycogendoi:10.1074/jbc.m107977200 pmid:12052822 fatcat:kcpb4r2xbramvl6haeyxct6yti