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Membrane Permeabilization by Poliovirus Proteins 2B and 2BC
Journal of Biological Chemistry
Poliovirus infection leads to drastic alterations in membrane permeability late during infection. Transient expression of each nonstructural protein of poliovirus by means of recombinant vaccinia virus encoding the T7 RNA polymerase indicates that proteins 2B and 2BC strongly enhance membrane permeability to hygromycin B in HeLa cells. Almost no effect on expression of proteins 2C, 3A, 3AB, and 3C was found. Deletions and point mutations in 2B and 2BC have identified sequences in 2B involved indoi:10.1074/jbc.271.38.23134 pmid:8798506 fatcat:whknyszx55aazmw737v2d4c5k4