FACTORS AFFECTING PROGNOSIS OF TUBERCULOUS MENINGITIS IN SAIFUL ANWAR GENERAL HOSPITAL MALANG
Malang Neurology Journal
The mortality rate of tuberculous meningitis (TBM) is approximately 20-41%. The prognosis is influenced by clinical and radiological features, laboratory findings, and therapy. Objective: To report factors affecting the prognosis of TBM patients in Dr. Saiful Anwar Hospital. Methods: The study design was a retrospective cohort with consecutive sampling. Data were collected from medical records of 47 patients from 2016-2017. Researchers used modified Rankin Scale (mRS) as prognostic value (good
... nostic value (good prognosis (mRS 0-2) and poor prognosis (mRs 3-6). The impact of clinical, radiological, and laboratory factors were analyzed by univariate analysis and multiple logistic regression. Results: In this study, good (n=21) and poor (n=26) prognosis were compared. Patients with good prognosis experienced more episodes of seizure than poor prognosis (17% vs 4%; p = 0.011). Focal neurologic deficits were more frequent in poor prognosis (4% vs. 23%, p = 0.012). Meningeal enhancement was more common in poor prognosis (21% vs 42%; p= 0.038). From multivariate analysis, researchers found that seizure and focal neurological deficit are independent prognostic factors (p=0.023 and p 0.033). Conclusion: Clinical factors influencing prognosis of TBM in Dr. Saiful Anwar Hospital are seizure and focal neurological deficit. Focal neurological deficit is a poor prognostic factor.