尿中酸化的DNA損傷を指標とした腎発癌物質スクリーニングの試み

山口 雷藏, 平野 雄, 葛西 宏, 松本 哲朗
2000 The Japanese Journal of Urology  
MethOds・ IKIR − S跚 跏 職 w 卿 hod刪 ge【retic alteratioms of 山e b− caterin gene 血 RCC a冂d TCC cell lines md turnor specimens . h sitU i 黜temh was detected by m し mohist hemical n 麒indin " prirnary an 【 1 12 rnetastatic ROC , mi 81 IXimary rCC . Wes 町 n blet analysis was also applied to 血 e cell Iines and some tumor samples . Resv 血 s . ( c al繊 血 s 血 吐re imiin gene R 翻 T ℃C w e mt 剛 曲 med 劇 m b s m 祕 v 輙 of w 邸 ( ibserved in e R ( 15. 5% ) and ・ TUC ( 24, 7%)and was o 。 melated With aharK) ed stages
more » ... nd n ( 測 involverrient 洫 RCC , and advanoed stages and multip 豆 e tumors in 1(] C . Conclusi 〔 ns . ( } enetic alterations b ℃ atenin do n σ [ play a significant role in RCC or TCC . Dowmegulati 。n of normal btatenin expressior1 might co 面 b蹴 じ o 丗 e m 討i 即 ant c r of RCC 跏 d 1℃ C . HQW 巳ver 曲 8 ev t鱈 mt m 血 lep 齟 lm 帥 os 丘 c r f匪 一 e or
doi:10.5980/jpnjurol.91.392_1 fatcat:mayani4isbempcxqtjakbstfie