First Quarter Screening for Aneuploidy

Florina Nela Osvar, Adrian Ratiu, Florica Voita-Mekeres, Gabriel Mihai Mekeres, Florin Gheorghe Voita, Ahmed Abu-Awwad, Marius Bembea
2020 Revista de Chimie  
The objective of this paper is to evaluate the rate of detection of chromosomal abnormalities through the non-invasive prenatal test (NIPT) and its contribution to reducing the number of invasive tests. We conducted a prospective study on a batch of 3,000 single-pregnancy pregnancies highlighted in the first trimester. The patients were divided into two study groups, the first group, which we will call the TPNI (Non-Invasive Prenatal Test) group. First trimester screening was performed by
more » ... performed by non-invasive prenatal test at 10 weeks, and ultrasound between 11-13 +/- 6 days according to the criteria of the Fetal Medicine Foundation (FMF. London, UK). The sensitivity, specificity and accuracy of the two screening methods are almost similar, using NITP screening we obtain a rate of approximately 20% lower false-positive results, and we also perform a smaller number of invasive tests.
doi:10.37358/rc.20.1.7851 fatcat:ldmm3nkjr5f4jd63nwmp7g2obm