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Loss of p16INK4 expression by methylation is associated with lifespan extension of human mammary epithelial cells
Inactivation of p16INK4 tumor suppressor gene function is frequently observed in breast cancer. We examined p16INK4 expression in human mammary epithelial cell (HMEC) cultures established from four normal donors. Normal HMECs divide a limited number of times before proliferation ceases in a state referred to as selection (or M0). The cell subpopulation that emerges spontaneously from selection undergoes a further limited period of proliferation before senescence. By immunofluorescence andpmid:9721850 fatcat:mo43btvn5zfandd4tggcn6zfxa