A Case of Acute Promyelocytic Leukemia after Iodine-131 Treatment for Thyroid Cancer

Sang Hun Lee, Ki Seong Eom, Seok Lee, Hee-Je Kim, Chang-Ki Min, Sung Yong Kim, Byung Sik Cho, Hyuk Lee, Chan-Kwon Park, Seok-Goo Cho, Dong-Wook Kim, Jong-Wook Lee (+2 others)
2006 The Korean Journal of Hematology  
Radioactive iodine ( 131 I) has been used in the treatment of thyroid cancer to eliminate residual thyroid tissue after thyroidectomy and to treat metastatic disease. Leukemia has rarely been reported as a late complication of 131 I therapy, occurring most frequently after receiving a cumulative activity of 800 mCi of the radioisotope. Although FAB M3 type (acute promyelocytic leukemia, APL) as the secondary acute leukemia had been rarely reported, recently there have been a few cases of
more » ... -related APL leukemia seen. We hereby report a case of secondary acute promyelocytic leukemia occurring in a patient who received radioactive iodine therapy for papillary thyroid carcinoma. An assessment of causality using the Naranjo probability scale showed that a possible relationship existed between APL seen in the patient and the use of the radioactive iodine. Although this is a very rare event, strict hematologic follow-up of patients treated with radioactive iodine may be warranted, along with a high index of suspicion in those with coagulopathy. (Korean J Hematol 2006;41:302-305.)
doi:10.5045/kjh.2006.41.4.302 fatcat:x4d534prdrasteymulw2kj4zu4