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The cDNA of the common a-subunit of human glycoprotein hormone was mutated by site directed mutagenesis in the CMGCC region composed of cysteine-methionine-glycine-cysteine-cysteine (position 28-32). The cDNA of wild-type human thyrotropin (hTSH) f3-subunit and that of wild-type or mutant common a-subunits were co-transfected into COS-I cells. The concentration of hTSH determined by two immunoradiometric assay systems was detectable in culture media of COS-I cells transfected with wild-typedoi:10.1507/endocrj.45.467 pmid:9881895 fatcat:djrf5kvrbfhopgrwnu4yp5gb4q