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Fibrin gel improves tissue ingrowth and cell differentiation in human immature premolars implanted in rats
INTRODUCTION In pulpless immature human premolars implanted in rodents, this study investigated whether fibrin gel offered advantages over leaving the root canal empty regarding soft tissue ingrowth and cell differentiation. METHODS Root canals of extracted human immature premolars (n = 12) were accessed and then irrigated with 5% sodium hypochlorite followed by 17% ethylenediaminetetraacetic acid. Root canals were then either left empty or filled with a fibrin gel (n = 6 each) before beingdoi:10.5167/uzh-99849 fatcat:es6yuujgejbavpsuv6xjspmrgm