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Myocardial Fibrosis in Fabry Disease Demonstrated by Multislice Computed Tomography
2003
Circulation
A 54-year-old man presented with dyspnea on effort. Echocardiogram revealed reduced apical wall motion of the left ventricle (LV) with extreme hypertrophy of the interventricular septum (IVS). Conventional coronary angiogram showed normal coronary arteries. Endomyocardialbiopsy specimens obtained from the IVS revealed extensive vacuolization of cardiac myocytes and mild fibrosis on light microscopy, and typical lysosomal inclusions with a concentric lamellar configuration were seen with
doi:10.1161/01.cir.0000062036.35852.01
pmid:12756193
fatcat:7fg5buabonf7detfgqsepwu63i