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Suppression of STAT5A increases chemotherapeutic sensitivity in imatinib-resistant and imatinib-sensitive K562 cells

Buket Kosova, Burcin Tezcanli, Huseyin Atakan Ekiz, Zeynep Cakir, Nur Selvi, Aysegul Dalmizrak, Melis Kartal, Ufuk Gunduz, Yusuf Baran
2010 Leukemia and Lymphoma  

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STAT proteins are cytoplasmic transcription factors that are involved in the regulation of numerous cellular activities such as cell growth, differentiation, and survival. In this study, we aimed to identify the expression pattern of STAT genes in imatinib-sensitive and -resistant K562 cells, and further, to reveal the effects of STAT5A siRNA knockdown on cell growth and apoptosis induction. The XTT cell proliferation assay showed that both sensitive and resistant K562 cells were sensitized to
more » ... matinib upon transfection with STAT5A siRNA. Caspase-3 enzyme activity was increased significantly in both cells. These results may open up new opportunities to overcome chemotherapeutic resistance in leukemia.
doi:10.3109/10428194.2010.507830 pmid:20849385 fatcat:64oz3v3jgvedflrs4tdq2gwb2i
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Buket Kosova, Burcin Tezcanli, Huseyin Atakan Ekiz, Zeynep Cakir, Nur Selvi, Aysegul Dalmizrak, Melis Kartal, Ufuk Gunduz, Yusuf Baran. "Suppression of STAT5A increases chemotherapeutic sensitivity in imatinib-resistant and imatinib-sensitive K562 cells." Leukemia and Lymphoma 51.10 (2010) 1895-1901