Alcohol Intake and Renal Cell Cancer in a Pooled Analysis of 12 Prospective Studies

J. E. Lee, D. J. Hunter, D. Spiegelman, H.-O. Adami, D. Albanes, L. Bernstein, P. A. van den Brandt, J. E. Buring, E. Cho, A. R. Folsom, J. L. Freudenheim, E. Giovannucci (+15 others)
2007 Journal of the National Cancer Institute  
The association between alcohol intake and risk of renal cell cancer has been inconsistent in case -control studies. An inverse association between alcohol intake and risk of renal cell cancer has been suggested in a few prospective studies, but each of these studies included a small number of cases. Methods We performed a pooled analysis of 12 prospective studies that included 530 469 women and 229 575 men with maximum follow-up times of 7 -20 years. All participants had completed a validated
more » ... ood-frequency questionnaire at baseline. Using the primary data from each study, the study-specific relative risks (RRs) for renal cell cancer were calculated using Cox proportional hazards models and then pooled using a random-effects model. All statistical tests were two-sided. Results A total of 1430 (711 women and 719 men) cases of incident renal cell cancer were identified. The studystandardized incidence rates of renal cell cancer were 23 per 100 000 person-years among nondrinkers and 15 per 100 000 person-years among those who drank 15 g/day or more of alcohol. Compared with nondrinking, alcohol consumption ( ≥ 15 g/day, equivalent to slightly more than one alcoholic drink per day) was associated with a decreased risk of renal cell cancer (pooled multivariable RR = 0.72, 95% confidence interval = 0.60 to 0.86; P trend <.001); statistically significant inverse trends with increasing intake were seen in both women and men. No difference by sex was observed ( P heterogeneity = .89). Associations between alcohol intake and renal cell cancer were not statistically different across alcoholic beverage type (beer versus wine versus liquor) ( P = .40). Conclusion Moderate alcohol consumption was associated with a lower risk of renal cell cancer among both women and men in this pooled analysis.
doi:10.1093/jnci/djk181 pmid:17505075 fatcat:qxbfto6u2jeormb3flscluhiii