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The pathophysiology of heart failure: a tale of two old paradigms revisited
2008
Clinical medicine (London)
Although our current appreciation of the detrimental role of neurohumoral activation in heart failure (HF) has been intellectually appealing and has led to neurohumoral antagonism that has reduced morbidity and mortality from HF, the persisting disability and death rates remain unacceptably high. In the search for novel strategies to improve on these outcomes, we must reacquaint ourselves with basic cardiac physiology at levels ranging from the molecular to the systemic in order to identify new
doi:10.7861/clinmedicine.8-2-192
pmid:18478870
pmcid:PMC4953007
fatcat:6chjwtfvnbddji7jh27hdag7zy