The concept of an "information space" provides a powerful metaphor for guiding the design of interactive retrieval systems. We present a case study of related article search, a browsing tool designed to help users navigate the information space defined by results of the PubMed Ò search engine. This feature leverages content-similarity links that tie MED-LINE Ò citations together in a vast document network. We examine the effectiveness of related article search from two perspectives: a

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... l analysis of networks generated from information needs represented in the TREC 2005 genomics track and a query log analysis of real PubMed users. Together, data suggest that related article search is a useful feature and that browsing related articles has become an integral part of how users interact with PubMed. Published by Elsevier Ltd. (J. Lin), dicuccio@ncbi.nlm.nih.gov (M. DiCuccio), grigoryv@ncbi.nlm.nih.gov (V. Grigoryan), wilbur@ncbi.nlm. nih.gov (W.J. Wilbur). 1 Or passages, records, audio clips, pictures, etc. -whatever unit of retrieval a system operates on.