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Antiapoptotic and antioxidant effects of resistance training with berberine consumption on diazinon induced cardiotoxicity in rats

Reza Niazi, Maghsoud Peeri, Mohammad Ali Azarbayjani, Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran, Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran, Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran
2020 Journal of Medicinal Plants  

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Keywords: Antioxidant Apoptosis Berberine Diazinon Resistance training Background: Increasing use of pesticides is one of the health hazards. Physical activity and medicinal plants appear to be a strategy to mitigate the adverse effects of these substances. Objective: The purpose of this study was to investigate the effect of resistance training and berberine chloride on apoptosis and oxidative stress markers in the heart tissue of diazinon-infected rats. Methods: In this study, 80 rats were
more » ... domly assigned into 8 groups of 10 animals in each group, including: 1) healthy control, 2) sham, 3) diazinon, 4) diazinon + resistance training, 5) diazinon + berberine (2.5 mg/kg) 6) diazinon + berberine (15 mg/kg), 7) diazinon + resistance training and berberine (2.5 mg/kg), and 8) diazinon + resistance training and berberine (15 mg/kg). During 4 weeks, each groups received a certain amount of diazinon poison, berberine chloride and performed three sessions per week of resistance training. Results: In the heart tissue of diazinon-poisoned rats, resistance training had a significant (P ≤ 0.05) effect on the increased concentrations of MDA, caspase-3, 8-OHDG and GSH; 15 mg/kg of berberine consumption had a significant effect on decreased concentrations of ROS, MDA, 8-OHDG, caspase-3 and increased (P ≤ 0.05) concentrations of GSH; 2.5 mg/kg of berberine consumption had a significant (P ≤ 0.05) effect on reduced 8-OHDG. Also, 15 mg/kg of berberine consumption compared to 2.5 mg/kg of berberine consumption had a greater effect on reduced 8-OHDG. Conclusion: It seems that berberine consumption along with resistance training has interactive protective effects against oxidative stress and cell death in the heart tissue of diazinon-poisoned rats.
doi:10.29252/jmp.1.73.71 fatcat:vfnrthu3dbdytiv55zotgsd4si
lang:fa
Citation

Reza Niazi, Maghsoud Peeri, Mohammad Ali Azarbayjani, Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran, Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran, Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran. "Antiapoptotic and antioxidant effects of resistance training with berberine consumption on diazinon induced cardiotoxicity in rats." Journal of Medicinal Plants 1.73 (2020) 71-81