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Determination of Non- 1-Antichymotrypsin-complexed Prostate-specific Antigen as an Indirect Measurement of Free Prostate-specific Antigen: Analytical Performance and Diagnostic Accuracy
2003
Clinical Chemistry
A new assay measures prostate-specific antigen (PSA) not complexed to ␣ 1 -antichymotrypsin (nACT-PSA) after removing PSA complexed to ACT by use of anti-ACT antibodies. We evaluated nACT-PSA and its ratio to total PSA (tPSA) as alternatives to free PSA (fPSA) and its ratio to tPSA in differentiating prostate cancer (PCa) and benign prostatic hyperplasia (BPH) in patients with tPSA of 2-20 g/L. Methods: PSA in serum of 183 untreated patients with PCa and 132 patients with BPH was measured
doi:10.1373/49.6.887
pmid:12765984
fatcat:kjprtfhckvbhjj6abwfcov7smy