Potential anti-adipogenic activity of Calligonum comosum cuminaldehyde on mouse 3T3-preadipocytes [article]

Mohammad G Mohammad, Ahmed El-Serafi, Mohamed I. Madkour, Abeer Alhabshi, Ansar Wadea, Rula AboJabal, Divyasree P P, Sameh S.M. Soliman
2020 bioRxiv   pre-print
Obesity is a medical condition associated with serious medical and psycho-social consequences and an augmented body fat mass. Several compounds were suggested to counteract obesity and fat accumulation with variable degrees of success. Searching for a safe and effective anti-adipogenic substance, we found that cuminaldehyde-rich essential oil extracted from Calligonum comosum potentially mediate activities. The results showed that C. comosum essential oil and its major component cuminaldehyde,
more » ... ent cuminaldehyde, selectively caused significant reduction in the viability of 3T3-L1 cells when compared to fibroblasts. Furthermore, cuminaldehyde caused significant reduction in the lipid content, glucose uptake and levels of both triglycerides and cholesterol in adipocytes. Moreover, the formation of 3D-adipocyte pellets in the presence of cuminaldeyde was affected. Adipocytes matured in the presence of cuminaldehyde have significant reduction in the expression of adipocyte-specific transcripts, CAAT-enhancer binding protein alpha (CEBPa) and Peroxisome proliferator-activated receptor gamma (PPARg). Taken together, these results demonstrate a potential inhibitory role of cuminaldehyde extracted from C. comosum oil on lipid accumulation. Consequently, cuminaldeyde can be considered as a new potential anti-adipogenic agent for prevention and treatment of obesity.
doi:10.1101/2020.07.02.184200 fatcat:v6m4kpmidjcbvfao5y7vojdxoi