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Focal epilepsy modulates vesicular positioning at cortical synapses
Neuronal networks' hyperexcitability often results from an unbalance between excitatory and inhibitory neurotransmission; however, underlying synaptic alterations leading to this condition remain poorly understood. Here, we assess synaptic changes in the visual cortex of epileptic tetanus neurotoxin-injected mice. Using an ultrastructural measure of synaptic activity, we quantified functional differences at excitatory and inhibitory synapses. We found homeostatic changes in hyperexcitabledoi:10.1101/2020.01.05.895029 fatcat:6nrgifn24zdmzob3yqy3efoq3e