Solid-pseudo papillary tumor (SPPT) of the pancreas is a very rare tumor and very few case studies has been published from India. Aims and Objectives: To evaluate the clinical presentations SPPT of pancreas and to discuss the treatment, radiological, histopathological and immunohistochemical (IHC) findings with cytogenetic work up and subsequent follow up of the patients. Materials and Method: We retrospectively reviewed the six patients with SPPT managed in our hospital between 2008 to 2016.

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... l the six cases were noted in females and their age ranges from 15 to 25 years. The clinical diagnosis were confirmed with ultrasound and computerized tomography. Distal Pancreatectomy along with splenectomy in two cases and Whipple's procedure was performed in other four cases. Cytogenetic workup was done in two cases. Results: The tumors were large, well encapsulated with mean diameter of 7 cm's, had solid and cystic areas and were distributed in head, body and tail of pancreas. IHC findings revealed tumors, positive for neuron specific enolase, cytokeratin, progesterone, vimentin and focal positivity for chromogranin, and synaptophysin. The follow up of the patient revealed pseudo cyst of pancreas in one case. Cytogenetic work up revealed derivatives of 17 th , 13 th , 9 th chromosomes. Conclusion: SPPT is a rare tumor with good prognosis after surgical resection.