Synthesis and Biological Assessment of New 1,2,4-Triazole Derivatives

Singala Pm, Talpara Pk, Shah Vh
Present work illustrates synthesis and biological evaluation of substituted 1,2,4 trizole derivatives. Synthesis carried out by condensation reaction of benzothiamide derivative with 2,2,2-trifluoroacetohydrazide to give 1,2,4-triazole, which further modified by N-alkylation and Suzuki Miyaura coupling reaction. Furthermore, the characterization of product is carried out by elemental analysis and spectral analysis. Products were evaluated for their in vitro biological assay for antibacterial
more » ... or antibacterial activity against various bacterial standard strains i.e., S. pyogenes MTCC-442, S. aureus MTCC-96, E. coli MTCC-443, and B. subtilis MTCC-441 and antifungal activity against Aspergillus niger MTCC-282 and Candida albicans MTCC-227 at different concentrations, results were compared with standard drugs.